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Biomarker: FABP3 (Cardiac panel)

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Analyte:

FABP3 (Cardiac panel)

Platform:

Matrix:

Rat Serum

Disease State:

Toxicity

Status:

Experienced Running

Required Sample Volume:

25 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 0.130 ng/mL
ULOQ: 94.5 ng/mL

Biological or Clinical Significance:

Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene.

FABP3 is known to interact with TNNI3K in the context of interacting with cardiac troponin I. The protein also interacts with, VPS28, KIAA159,NUP62, PLK1, UBC, and Xpo1.In HIV, a synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs.
H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the pain.

References:

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