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Biomarker: hIGF-1

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Analyte:

hIGF-1

Platform:

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Required Sample Volume:

Not specified

Sensitivity-LLOQ/ULOQ:

LLOQ: 46.9 pg/mL
ULOQ: 6,000 pg/mL

Biological or Clinical Significance:

Insulin-like growth factor 1 (IGF-1), also known as somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Human IGF-1 is a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges, with a calculated molecular mass of 7.6 kD. The IGF-1 gene, mapped on 12q22-q24.1, contains 5 exons.

IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). Furthermore, IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

References:

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