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Biological or Clinical Significance:

Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells.

IL-21 has been tried as therapy for alleviating allergic responses. It was shown to be successful in decreasing pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis. IL-21 was approved for Phase 1 clinical trials in metastatic melanoma (MM) and renal cell carcinoma (RCC) patients. It was shown to be safe for administration with flu-like symptoms as side effects. Dose-limiting toxicities included low lymphocyte, neutrophil, and thrombocyte count as well as hepatotoxicity. IL-21 may be a critical factor in the control of persistent viral infections.

References:

Analyte:

IL-21

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Sensitivity-LLOQ:

10.5 pg/mL

Sensitivity-ULOQ:

42,900 pg/mL

platform

Luminex

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

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