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Biological or Clinical Significance:

IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31 is believed to play a role in inflammation of the skin.

References:

  • Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (July 2004). “Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice”. Nat. Immunol. 5 (7): 752–60.

Analyte:

IL-31

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Sensitivity-LLOQ:

46.3 pg/mL

Sensitivity-ULOQ:

75,300 pg/mL

platform

Luminex

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

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