Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in humans is encoded by the MMP1 gene.[1][2][3] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1] MMP-1 was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA.

MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Specifically, MMP-1 breaks down the interstitial collagens, types I, II, and III. Mechanical force may increase the expression of MMP1 in human periodontal ligament cells. In addition, MMP1 has been shown to interact with CD49b.