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Biomarker:

Neurofilament Heavy (NF-H)

Biological or Clinical Significance:

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

References:

Analyte:

Neurofilament Heavy (NF-H)

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

7.47 pg/mL

Sensitivity-ULOQ:

platform

Ella

Required Sample Volume

Disease State:

MSD Panel:

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