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Biological or Clinical Significance:

Placental growth factor (PGF)-expression within human atherosclerotic lesions is associated with plaque inflammation and neovascular growth. Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with preeclampsia. Studies show that in both early and late onset preeclampsia, maternal serum levels of sFlt-1 are higher and PGF lower in women presenting with preeclampsia. In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies. This suggests that placental concentrations of sFlt-1 and PGF mirror the maternal serum changes. This is consistent with the view that the placenta is the main source of sFlt-1 and PGF during pregnancy.

References:

Analyte:

PLGF

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Sensitivity-LLOQ:

6.08 pg/mL

Sensitivity-ULOQ:

5,464 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

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