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Biomarker:

TNF-α (plasma)

Biological or Clinical Significance:

Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction Iplays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. It is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. Shedding of membrane bound TNF-alpha by TACE (ADAM17) releases the bioactive cytokine. TNF-alpha binds TNF RI and TNF RII and induces apoptotic signaling through the death domain of TNF RI.

References:

Analyte:

TNF-α (plasma)

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Sensitivity-LLOQ:

0.584 pg/mL

Sensitivity-ULOQ:

244 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

Autoimmune

MSD Panel:

Proinflammatory Panel 1 (Human)

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