From The Stage

BioAgilytix Adds Extensive Capabilities with the Acquisition of MicroConstants and 360biolabs®️

Posted by BioAgilytix / / Uncategorized

BioAgilytix, a leading global contract research organization focused on supporting its pharmaceutical and biotech partners in all stages of drug development, recently acquired MicroConstants and 360biolabs®️. These acquisitions greatly expand the already impressive scope of BioAgilytix’s capabilities, scientific expertise and geographic footprint. As an independent bioanalytical testing industry leader, MicroConstants, now known as BioAgilytix San Diego, has been providing Good Laboratory Practice (GLP) compliant services for decades. Headquartered in San Diego, MicroConstants offers services such as method development and validation using Liquid Chromatography with tandem mass spectrometry (LC/MS/MS), High Performance…

Flow Cytometry in Bioanalysis: Application, Utility and Recent Advancements

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Flow Cytometry in Drug DevelopmentFlow cytometry is a technique that is used to analyze multiple characteristics of single cells. These characteristics include cell size, cytoplasmic complexity of the cell, as well as expression of cell surface and intracellular proteins. This unique technology utilizes fluidics, optics, and electronic components to interrogate each cell by lasers as it flows through the sample stream. The dispersed light and emissions from excited fluorophores are collected and directed toward photodetectors that isolate specific wavelengths and convert them to digitized signals in the form of numerical…

Update on CAR T-Cell Therapies for the Treatment of Cancer

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Chimeric Antigen Receptor (CAR) therapies are a type of cell therapy that consists of modifying immune cells to attack various forms of cancerous cells. While this is a relatively new therapeutic class, there are already a number of versions that are being developed or already approved for treatment.  Let’s start with the source of the cells being modified. In general, there are two categories of CAR immune cells: Autologous and Allogeneic. Autologous CAR therapies are derived from the patient’s own cells while allogeneic CAR therapies are typically taken from healthy donors…

Challenges for Measuring Immunogenicity of AAV-based Gene Therapies

Posted by BioAgilytix / / Uncategorized

Gene therapy is a powerful form of treatment that involves introducing genetic material into cells to replace defective genes resulting in the production of an essential protein. If a defective gene causes a required protein to be faulty or absent, gene therapy may be able to restore the protein’s function by introducing a “healthy” copy of the gene.Since gene therapy products work by introducing genetic material into the cell, scientists need a way to deliver DNA, RNA, or nuclease to the target tissue and cells. The delivery systems that carry…

Cell-Based NAb Assays: What We Need to Know

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Cell-Based NAb AssaysThe bioanalytical community adopts a tiered approach to tackle the problem of NAbs. Firstly, any study samples in question are first screened and confirmed for the presence of binding antibodies via an established immunoassay. If the sample tests positive for binding antibodies, it is then examined for any drug-specific neutralizing ability in a NAb assay. Standard immunoassays such as enzyme-linked immunosorbent assays (ELISA), electrochemiluminescent (ECLIA), and other assays can detect anti-drug antibodies, nevertheless fail to discriminate whether these antibodies are binding or neutralizing in nature. To detect NAbs,…

Cell and Gene Therapies Account for a Large Portion of the Therapeutics Market

Posted by BioAgilytix / / Gene Therapy, Industry Update

Cell and gene therapies have gone through a growth spurt in the last decade. According to data from the Alliance for Regenerative Medicine (ARM), during the first three quarters of 2020, regenerative medicine research and development broke records at nearly $16 billion in global financing. From the treatment of knee injuries to osteoarthritis, certain cancers and even muscular dystrophy, advances in gene and cell therapies have definitely caught the attention of medical professionals, and for good reason. Cell and Gene Therapies Account for a Large Portion of Therapeutic Market Share…

BioAgilytix Team Q&A: Meet Chris Carlin

Posted by BioAgilytix / / BioAgilytix Insight, CRO Selection

Tell us a little about your background and how you came to join BioAgilytix. My first wet lab experience was gained during my undergrad studies at Bowdoin College in southern Maine. I majored in biology and completed an honors thesis through an exploratory study of an uncharacterized genetic locus in a pathogenic yeast. Thereafter, I moved to Boston and worked for three years at the Ragon Institute of MGH, MIT and Harvard, where I analyzed expression profiles of proteases in the blood cells of HIV+ patients. I then transitioned into…

BioAgilytix Team Q&A: Meet Reema Davis

Posted by BioAgilytix / / BioAgilytix Insight, CRO Selection

Tell us a little about your background and how you came to join BioAgilytix. I did my doctoral and postdoctoral training in Cell Biology. My fascination with blood and lymphatic vessels led me to research their genetic make-up and related diseases, in hopes to find potential drug targets. During my research I trained extensively in cell-based work including but not limited to gene expression studies, intracellular signaling, cellular staining, transduction, all of which helped me build a strong foundation of transferable skills. I interviewed at BioAgilytix through Hannah Powell’s referral…

BioAgilytix Team Q&A: Meet Nikhil Soni

Posted by BioAgilytix / / BioAgilytix Insight, CRO Selection

Tell us a little about your background and how you came to join BioAgilytix. Some of my friends at my previous job joined BAL and told me about how much they liked it here. What is your current role, and how has it evolved since joining the team? Scientist III/BPM. Since joining the team I’ve had 4 analysts and scientists added under me. Along with that I’ve been given the responsibility of managing all aspects of multiple large studies. This has given me a lot of experience in both project…

New Opportunities for Women in Science and Technology

Dominic Marasco
Posted by Dominic Marasco / / Uncategorized

In the last decade, women have made significant strides in their professional lives and scholarly pursuits. Even the political world has seen a boom in women running for public office. With all of these glass ceilings being shattered and hierarchical norms being reimagined, there is one industry that could use a boost. The Science, Technology, Engineering, and Mathematics (STEM) sector is seeing an increase in the number of women entering these industries, but there is always room for more.According to The American Association of University Women (AAUW), women only make…