Webinar Recording: Clinical relevance of (unwanted drug-induced) immune responses
Ultimately, all biological drugs are immunogenic. Over the last several years, methods for the detection of drug-induced antibodies have become more sensitive, which means that target sensitivities of 100 ng/mL can be easily reached. But, the question remains to be answered: are antibodies at this low concentration level clinically relevant? In addition, do antibodies against biological drugs that are detectable prior to the initiation of the treatment have any clinical implication? This webinar will discuss why careful and thorough data interpretation is needed, which takes into account the clinical manifestation of clinically relevant biomarkers (including PK).