Pirfenidone and its Metabolites 5-Carboxy-Pirfenidone and 5-Hydroxy-Pirfenidone Toxicokinetics in Rats Following Inhalation of a Nebulized Aerosol Formulation

Purpose

To assess the toxicokinetics (TK) of pirfenidone (AP01) and its main metabolites 5-carboxy-pirfenidone and 5-hydroxy-pirfenidone during a 26-week oronasal rat inhalation toxicity study.