Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3′,5′-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway.
Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.
- Rahman N, Buck J, Levin LR. pH sensing via bicarbonate-regulated “soluble” adenylate cyclase (sAC) Front Physiol. 2013 Nov 25;4:343. eCollection 2013. Review. PMID 4324443
- GeneGlobe -> GHRH Signaling Retrieved on May 31, 2009
- American Association for Cancer Research (cAMP-responsive Genes and Tumor Progression)